Ledebouria lepida is best cultivated in a clean, fine, sharp, sandy soil with good drainage. The addition of a small amount of sifted kraal (cattle) manure and a little bone meal is beneficial. This species is not well suited to being grown in the garden, partly due to its small size, but also due to its specific soil and environmental requirements. Plants require a warm climate with watering in the form of heavy downpours between each period of almost complete drying out in summer. They should be kept in a full sunny position and exposed to rain; shaded plants tend to become floppy. During the dry winter dormancy period the pots should be moved out of the rain and placed in a cool dry area with good air movement. Watering can commence at the onset of warmer weather in spring (September to October in South Africa).

Propagation from seed is a successful method of producing more plants. Seed can be left to drop in the mother pot where it will germinate and develop around the parent plants. In the nursery, seed should be sown in spring or summer in seed trays filled with a sifted sandy soil with good drainage, with some sifted manure added. The seed can be sown on a firmly tamped surface and lightly covered with the same mixture approximately 1–3 mm deep. The trays should be kept in a bright, warm, well-ventilated position out of direct sunlight, and kept damp for between 1 and 3 weeks, until germination has commenced. Once the seedlings have emerged, watering can be gradually reduced and sunlight can be increased. Bulblets can remain in the seedling tray for 1 year or more and planted out at the beginning of their second or third growing season. Flowering size bulbs can be attained after two to three years.