Crossyne guttata ismost suited to grow in pots or in dedicated rock garden pockets, that are kept absolutely dry in summer. Like most bulbs, mass planting is always a good option for a nice display. They require full sun or very bright light for as much of the day as possible. The bulbs are planted with the top of the neck at, or just below the soil level, needing sporadic drenching, approximately once every 2 weeks, in winter.

When growing it in congtainers, plant in large pots, preferably one in each pot, as the bulb has a large inflorescence. This will also give the grower full control of the plant as it needs to be kept completely dry in summer. Also take note to place the bulbs in sunny positions as they prefer full sun.

Sow seed in autumn, in deep containers as soon as the seed is ripe. The seedlings normally reach maturity in a minimum of 7 to 8 years under ideal conditions, thereafter will flower intermittently. An ideal soil mix for this bulb is river sand and bark, in a ratio of 2:1.

In cultivation the plants are irregular in flowering. Some forms of C. guttata flower consistently every year in cultivation, whereas, others hardly ever flower. In the wild, the species blooms in abundance within weeks of wildfires.

These plants are normally attacked by lily borer caterpillars, with the bulb tunics sometimes infested with mealy bug. These can be treated by over the counter insecticides or home remedies.