Aloe reynoldsii grows very well in cultivation and is suitable for rockeries and water-wise gardens, where the winter is cool with no frost and also as a pot plant. It grows well in semi-shaded areas with morning sunlight and afternoon shade and must be planted in a well-drained soil. During hot weather, water once a week and twice a month in normal summer temperatures, and once a month in winter. When mature plants are removed from the soil, or are being transplanted into bigger pots, leave the plant out of the soil for 2 to 3 days to dry and cut off the old roots to prevent rotting of the root system and promote growth of new roots.

Aloe reynoldsii can be propagated using both sexual (seed sowing) and asexual (stem cutting) propagating methods. Sow seed during the warm months on coarse river sand and slightly cover the seeds with a layer of sand, not more than 2 mm deep, and keep the medium moist. Seeds germinate after 2 to 3 weeks. Transplant the seedlings after 1 to 2 months. Seedlings must be transplanted into a medium consisting of 2 parts coarse river sand and 1 part of well-rotted compost. Branches can be cut off using a clean, sharp instrument. Allow the cut stem to dry in a cool, airy place, away from direct sunlight, for a few days until the cut ends have formed a callus. Plant the callused stem in a well-drained potting medium, in a lightly shaded spot, keep moist but not wet.

Aloe reynoldsii is prone to aloe cancer, white scale, aphids, rust and they can be controlled by a fungicide or pesticide application. Prevent plant infection by sterilizing your medium, tools, only using disease-free seeds, and also monitor pest and control them at an early stage to prevent spreading.