Ledebouria cremnophila is easily maintained in cultivation, ideally it should be grown in a terracotta pot in a well-drained, potting medium comprised of well-rotted compost or leaf litter mixed with equal parts of coarse, sandy loam. The potting medium should provide slightly acidic, humus-rich growing conditions, the addition of well-rotted kraal manure, is beneficial. Watering should be frequent during the summer months. The plants prefer a warm summer climate, with good air circulation and the soil should be allowed to almost dry out between watering. Growing the plants in full sun will ensure an attractive and compact growth habit, as well as maintain optimum leaf colouration and encourage darker markings on the leaves. During the dry winter dormancy period the pots should be watered only very lightly once every 4 to 6 weeks, to maintain some moisture content in the growth media. Watering can commence towards the end of winter at the onset of warmer temperatures (August–September in South Africa).

Since this species rarely produces offset bulblets, propagation from seed is the best method of producing more plants. Sow seeds immediately, do not store them, in spring or summer, in shallow seed trays filled with the sifted potting mixture mentioned above. Spread the seed evenly on a firmly tamped surface and lightly cover with the same mixture, approximately 2 mm deep. The trays should be kept in a bright warm position out of direct sunlight and kept damp until germination has commenced. Watering can be gradually reduced post germination, to reduce the incidence of fungal infection. Seedlings can remain in the seedling tray or planted out as soon as they are big enough to handle. Flowering size bulbs can be attained after 3 to 4 years after germination.