Kleinia longiflora is a hardy plant that does best in full sun as a potted specimen. In cultivation it can tolerate semi-shade and it does not flower as freely as it does in its natural habitat. It is also suitable for arid and rock gardens. In the winter rainfall area it can be planted together with companion plants such as Aloe striata (with light blue-green leaves and bright orange flowers), Didelta spinosa (yellow flowers), Eriocephalus africanus (white flower heads), Kalanchoe thyrsiflora (with their attractive red leaf margins with yellow flowers) and Lessertia frutescens (orange-red flowers).

Propagation can be from seeds or cuttings. Sow seeds in autumn, horizontally, 2–3 mm deep in a well-drained, sandy soil. They germinate within a week at temperatures between 15ºC and 30ºC, with little or no dormancy, and produce large first leaves (10 mm) from their cotyledons. The succulent stem then forms, slowly reaching about 50 mm after a year. Plant the seedlings into soil with minimal organic matter, in small pots, after one year. Add a mulch of stones to protect the stem base from sunburn and to prevent irrigation washing away soil, as this causes the cylindrical succulent to fall over.

Kleinia longiflora can also be grown from cuttings that include nodes. They are vulnerable to rotting in hot weather, so cuttings are best taken in autumn and winter, from April to September. Allow the wounded area to dry for about 3 to 4 days). Renu Karoo veld restoration CC does not use rooting hormone on their succulent cuttings. Rooting takes 4–6 months. (Milton, S. pers. comm. 2019).