All propagation is best done in spring which is the start of the growing season. Streptocarpus molweniensis can easily be grown from seed as well as cuttings, just as most species of Streptocarpus.

When germinating this species, because of its very fine seeds, mix them with white silica sand to assist with spreading the seeds evenly and to prevent sowing too densely on the tray. Use a well-drained medium that is not too coarse. A mixture of 1 part peat and 1 part sand/perlite has proven to be more effective. Cover the sown seed with a very thin layer of fine sand and keep in a warm place, away from direct sunlight.

Vegetative propagation or cuttings is another way of propagating this species. Fresh healthy leaf is sliced off the central vein, separating the leaf into 2 halves, or slice the leaf across to have multiple pieces. Place the cut pieces in the potting soil with the exposed side (cut part) of the leaf towards the soil. Keep the medium moist, not damp or wet, until the formation of shoots can be observed. Subsequently, new shoots can be observed after a 3–4 weeks, forming along the cut parts of the leaves. Once new shoots develop first true leaf, they can then be detached from the ‘parent leaf’ and be potted separately.

Better germination (seed propagation) or shoot (leaf cutting) results are often obtained if the tray is covered with a glass sheet or enclosed in a clear plastic packet, which keeps the soil surface constantly most.

Streptocarpus plants are prone to pests and diseases when they are not being treated or grown correctly. Some of the human errors in handling cultivated Streptocarpus are overwatering, underfeeding, rootbound plants and lack of good air movement/circulation. To keep Streptocarpus looking attractive, regularly remove all dead, unhealthy, dying leaves and flowers.

Caterpillars, mealy bug and fungal infection are the most troublesome pests and disease on Streptocarpus molweniensis. Pests such as caterpillars can be hand-collected or sprayed with a suitable poison. Mealy bug can be strayed with a suitable pesticide. If fungus is found on any part of the plant, treat with a suitable fungicide, improve the air circulation and take extra care not to overwater.