Aloes are quirky-looking plants that every gardener should try to have in the garden. Aloes offer striking flowers, architectural form and inspiring stature and have the ability to withstand tough conditions. Most can be used as accents to draw the eye through the landscape. For nature lovers, they have the added benefit of attracting a diverse range of birds and other wildlife to the garden.

Aloe simii does not produce offsets, so propagation is only possible, and is easy, by seeds. Harvest the seeds when the pod is green and not yet split open or else the seeds will all blow away. Seeds are black when ready, pale-coloured or white seeds are not ready to be harvested and will not germinate. Keep the pod in a container until it becomes dry and brownish, extract the light, flat, black seeds from the pod and discard the empty pod. Store the seeds in a paper envelope, in a cool dark place. The best time to sow the seeds is in spring or summer, when temperatures are warm. Sow the seeds when they are still fresh, in a seed tray filled with a well-drained sowing medium (e.g. 3 parts potting soil and 1 part river sand). The seed tray must be placed on a raised bench, in a warm area and covered with a net, until germination. The soil should be kept moist all the time, but not wet. Germination can be expected after 14 days. The germination rate of seeds may reach up to 90%.

Seedlings of Aloe simii can be transplanted into individual pots or plastic bags when they have produced 4 true leaves. The most suitable soil mixture for optimal growth of Aloe simii seedlings is 1 part river sand and 3 parts of potting soil. Bio-organic fertilizer is applied on the potted plants after transplanting. Seedlings should be placed under a shade net.

Aloe plants need to grow in a loose soil medium that will not get waterlogged and does not carry any pathogens or weeds.

The growing conditions for species of Aloe differ, depending on their natural habitat. Most aloes need full sun for at least 6 hours a day. Many varieties will benefit from partial afternoon shade. Full sun encourages flowering, and boosts the red and orange tones in the leaves. Once established, aloes require very little care.

Aloe simii will grow in full sun or partial-shade, preferring a well-drained position that is well-watered in spring and summer. This species can be used as border plant, beside paving and is suitable to be used as a container plant. It looks good growing together with Adenium swazicum and Kniphofia rooperi. Spring is the best time to plant Aloe simii because it does most of its growing in summer.

At the Lowveld National Botanical Garden, Aloe simii is affected by black spot disease on the leaves, fungicide is used to control the disease. White scale also affects Aloe simii, it starts off as a small infestation on the leaves but it can turn in to a serious infestation in a short period of time that can result in the death of the plant. Pesticides are used to control the pest.