Serruria zeyheri can be propagated by both seeds and cuttings. However, the seeds are not easy to collect or find as they drop immediately when ripe. The seeds are sowed in late summer to autumn (February to April) in the Western Cape, when the temperate begins to drop and it is cool during the nights. The seeds are treated with systemic fungicides prior to sowing to prevent pre-and post-emergence damping-off fungi and are exposed to smoke after sowing, to break the dormancy of the seed. Use a well-aerated fynbos medium, preferably between 5-7 pH levels.

Cuttings are done from summer to autumn, semi-hard cuttings are collected in the early morning while it is still cool. Cut them about 30-70 mm long and dip them in the semi-hardwood rooting hormone and insert in the propagation medium. Place the trays in the mist house on the warm benches of about 25°C until they start rooting. Move the rooted cuttings to the hardening off area for 2-3 weeks. Transplant the seedlings and cuttings in the bag or pots and let them grow until they are ready to be planted in the garden.

Feed the plants with organic fertilizers. To avoid root disturbance, dryness and weeds, apply a layer of 5 mm mulch in the bed. Chipping mulch is much recommended as it breaks down very slowly and releases small amounts of nutrients to the plants. The plants do not need pruning maintenance in the garden.