Removing offsets (side shoots) or tufts is the best way to propagate this species. In addition to seeds, cuttings, offshoots or layering, several plant species can be reproduced by offsets, or division of tufts and rhizomes. Anginon difforme grows in tufts, and although no successful vegetative propagation procedures have as yet been attempted or described, this species can be cultivated vegetatively by dividing and breaking up plants. As a result, they are rarely started from seed. Tuft division is usually done in the spring, but it can also be done in the autumn and results in new plants with the same features as the mother plant. It is a simple procedure to do and is guaranteed to work. The plant is dug out from the ground or removed from a pot, then tufts are located and freed with the hands or with the help of a knife, taking care not to damage the roots. Plants should be planted or potted in a well-drained, acidic, sandy mix with a high humic content once they have been split, and placed in a sunny, well-ventilated place. When planted, the soil should be kept damp until they are well established, whereafter they require very little extra watering.

Sow seeds in a freely draining medium in autumn or winter. After levelling the medium, distribute the light seeds evenly over the surface, moisten gently, and cover with a thin layer of sand or fine-milled bark. Smoke treatments can be used to enhance germination. Place in a sunny location, because most species seeds in the Cape Floristic Region require sunlight to germinate. Within 2 to 3 weeks, the seeds will germinate. When the seedlings are large enough to handle, prick them out of the trays and pot them. Place the potted seedlings in a covered area, such as under a shade net, and gradually introduce them to full sun.

Anginon difforme grows with a range of fynbos species in its natural setting in the Cape Floristic Region, therefore it gets along with most of the other larger fynbos groups such as the Cape reeds (restios), proteas, ericas, and buchus.