Mesembryanthemum amplectens is easy to propagate by seeds sown in autumn, between March and May. With this species reproducing easily and effectively in the wild, seeds can be sown directly in the field, given that the soil conditions and environmental conditions of the garden are optimal. M. amplectens prefers to be grown in a position in full sun, with dry or limited-moisture soils. For nursery propagation, the growth medium for propagating this plant should contain a mixture of 60% coarse river sand and 40% sifted compost, but is not limited to the recommended growth medium, other germination mixes suitable for succulents may be used. The germination mix must be uniform and sifted to get rid of coarse particles and other objects that might limit the germination success. Use germination trays that are shallow, to allow satisfactory drainage and air circulation. Sow the seeds gently and evenly on top of the soil inside the trays and lightly cover them with the soil. Provide them with water using a fine sprayer so that the seeds will not be washed out of position, and keep the soil damp but not wet. Similar to its relatives, this species would probably take 2–3 weeks to germinate. Place seed trays and germinated seedlings under a roof that allows in some light but not direct sunlight, as that might be harsh for seedlings grown under proper care.

This ice plant has not been propagated by cuttings in the Karoo Desert National Botanical Garden. For some Mesembryanthemum species, other methods of propagation are recommended, depending on the plant, if there are any difficulties with seed germination or root development. The related species M. varians has previously been reproduced by cuttings at Karoo Desert National Botanical Garden. Riddles recommends that tip cuttings about 5 cm long are collected from a healthy mother plant in spring and planted in washed coarse river sand. Softwood rooting hormone can be used to promote rooting. Place the cuttings trays in a warm production house with light shade and water them with mist sprayer. Rooted cuttings should be transplanted into  well-drained soil containing organic content of at least 30%.

Transplanting must be done when the seedlings have grown large enough to be handled or when cuttings have rooted, ideally and on average this is two months after germinating or immediately after rooting. Ttransplanted seedlings must be moved to the hardening-off section, so that the plants get to adapt to brighter light and the external environment. The young plants will take quite some time to adapt when it has been moved from the nursery to an exposed area because it must adapt to new environmental conditions before growing. During this period, the plants must be very closely monitored.

In the garden, grow the plant  in sunny areas where the soil is sandy and well-drained, and where it will not be watered too much. It is suitable to be planted as a ground cover and for seasonal colour in the garden. The species M. varians is one of the species that requires almost the same treatment as M. amplectens. The plants can be affected by fungal diseases when it is not well maintained in the garden; such as receiving too much water, or being situated in soil that holds too much moisture, or where there is not enough circulation of air, and exposure to pests. When the plant is experiencing such difficulties, the grower should make sure that the cultural and mechanical methods of maintenance (primary control methods) are in place before opting to use fungicides. These control measures can include removing severely affected plants, spacing plants more widely by opening spaces in between the plants, removing weeds in the garden beds (weeds can act as pest and disease hosts) and making sure that the watering regime is suitable for their water requirements.