Acmadenia tetragona is not established in cultivation but has thrived in the motherstock beds at Kirstenbosch where it is planted on an east-facing slope in a sunny position with late afternoon shade and no irrigation. In the garden, it requires full sunlight, in an open, well-ventilated position with well-drained, acidic soil. It will benefit from being planted in well-prepared soil rich in compost and given a thick layer of mulch every year. Plants also respond favourably to slow-release fertilizer, such as 3:1:5. These plants are ideal for fynbos gardens, planted among other fynbos plants.

This plant is propagated vegetatively at Kirstenbosch NBG in the autumn, however attempts in other seasons are also possible. Take cuttings 25 to 55 mm long from the current year’s fresh growth. Remove around one-third of the foliage, cut below the node, and apply a rooting hormone. The rooting medium is a 50/50 mixture of fine-milled bark and perlite, but this might vary according on what is available. The cuttings are placed on a heated bench in a mist unit. Rooted cuttings are moved to a hardening section for roughly two weeks before being potted. Potted plants are placed in a shady region for up to two weeks to a month before they are moved to full sun area.