Serruria hirsuta is propagated by seed and cuttings. However, ensure that the plants are growing in soil with an acidic pH between 5 and 7. A higher or very low pH level causes the plants to suffer and eventually die. The seeds are sown in late summer to autumn (February to April), when the night temperature drops, to mimic the conditions in the wild. The seeds are treated with systemic fungicides prior to sowing to prevent infection by pre- and post-emergence damping-off fungi. The seeds are also treated with smoke derived from burning dry and green fynbos materials to break dormancy. A well-aerated fynbos sowing medium is used, such as a mixture of 50% vermiculite and 50% milled bark. The germinated seedlings are potted in a mixture of 25% vermiculite, 25% bark, and 50% fynbos soil medium, which ensures an exceptional survival rate for the seedlings.

Semi-hardwood cuttings are collected in midsummer and autumn (November to April). Disease-free cutting material is selected, the cut base dipped into a liquid rooting hormone for 5 seconds, or a powder hormone is applied to the cut surface. The cuttings are placed in multi-trays, in a well-drained and aerated medium consisting of 70% perlite and 30% fine-milled pine bark or coarse sand. Cuttings are normally rooted on benches heated between 24°C and 30°C and are regularly treated with fungicides to prevent fungal infection. Rooting takes about two to three months under mist-house conditions.

An organic seaweed-based fertilizer is applied to encourage the development of the sensitive proteoid roots. This is a slow-growing protea, so it is important to monitor water requirements and keep the plant free of weeds to avoid root disturbance. The plants require a garden position with well-drained, acidic soil, full sunlight, or semi-shade and good aeration. They grow well in gardens when placed on a slope or in a rockery and where their roots will be as undisturbed as possible. In the garden, the plants are mulched with wood chippings to keep the soil cooler and moister during the hot, dry season and to suppress weeds. Once the plants are established in the garden, they require very little maintenance.