Euphorbias are relatively easy to grow and maintain, provided they are kept within their habitat preferences. They grow best in high temperatures. They prefer well-drained loamy soil which helps prevent the roots from drying up during extended dry periods. Watering should be based on the species native habitat, with species from moist areas preferring regular watering in summer while those from drier areas can manage with receiving water once a week or even less often than that. Euphorbia schoenlandii, comes from the winter-rainfall area and prefers to be kept dry during the summer months and needs water during the winter months.

Seed is the best way of propagating E. schoenlandii. Collected ripe fruits from the mother plant and keep them a paper bag left in a dry, warm place to dry out. Once ripe, the capsules explode, forcing the seeds out. The seed coat can then be filed a little and sowed in a tray filled with seedling medium. Seeds should be sown within a month of release and not be kept for more than two years, as older seeds tend to have reduced germination rate.

E. schoenlandii can also be propagated from cuttings. Cuttings are not common in this species because the plant is rarely branched. To make a cutting, a branch must be cut off cleanly where it is constricted at its base and the cut stem must be left to dry out for about a week before being planted into a rooting medium, which should contain river sand. After planting, it’s important to keep the cutting stable to avoid damaging the developing roots. Regular watering is required at this stage. However, overwatering the cuttings may cause the stems to rot if they remain overly damp. The cuttings should be kept in a well-ventilated environment.