Grow Adenandra villosa in a sunny, well-ventilated position, in well-drained acidic soil suitable for fynbos. Feed with well-rotted compost added as a layer of mulch.

Similar to other species in the Rutaceae family, they can be either propagated by seed or by cuttings. To propagate by seed, prepare a well-drained medium using equal parts sand, loam and compost, and mix lightly. Place the medium in 100 mm deep trays with sufficient drainage holes. Flatten the surface lightly and water. The seeds should be spread evenly over the medium and covered with 3 mm of the medium. Trays should then be placed in a covered area that has good light and free air circulation. Make sure that the trays are kept damp. Seeds should germinate in one to two months.

To propagate by cuttings, take cuttings 50–70 mm long from the current year’s growth. The most successful cuttings are taken six to nine weeks after flowering. The cuttings should have a clean cut below the node, remove up to a third of the lower leaves. The cut end should be dipped in a rooting hormone and the cuttings should then be placed in trays filled with a medium of equal parts milled bark and polystyrene. Ideally the trays should be placed in a well-aerated propagation unit that has timed misting andbottom heating of 24°C, but if this is not possible, the trays could be placed within a plastic container where the leaves and the medium do not touch the plastic covering. Rooting usually occurs in nine to eleven weeks. 

Adenandra villosa could be affected by pests and diseases that other species in the Rutaceae family experience. It could be affected by the citrus caterpillar but this can be controlled with a contact stomach insecticide. Phytophthora cinnamomi is a common pathogen that affects many fynbos species and could also affect A. villosa. It thrives in soil with high temperatures and attacks the root system which prevents the plant from absorbing water causing the plant to eventually wilt and die. To prevent this, before planting young plants, treat them with acylalanine and try not to cause any root damage, add mulch to reduce the soil temperature and try not to disturb the soil.