Peperomia leptostachya is an easy to grow and care for plant which does well in light shade, dappled shade, semi-shade and shade with moderate watering needed. It grows best in a well-draining potting soil that is rich in organic matter but it must be kept moist.

The species can be successfully grown from seeds which should not be stored for a period of more than 3 months as they will lose their viability.

The species can also be propagated through stem cuttings which should be 8–10 cm long. Remove the lower leaves, flower spikes and trim the upper leaves in half when making cuttings. Use a low-concentration rooting hormone as the cuttings root very easily on their own, making use of a rooting hormone optional, though it enhances propagation success and uniformity.

For your cuttings, use a mix of 1 part perlite to 1 part peat moss and position them in a cool, shady location and keep them moist. Peat moss helps in retaining the needed moisture and nutrients the cuttings need to survive, while perlite promotes aeration to prevent root rot, ensuring optimal growth.

Peperomia leptostachya can be grown in the garden in warm, moderately well-watered climates, and it makes a green and unusual ground-cover in any shady area. Soil must be well-drained to avoid root rot. Add some compost to the soil when planting and water well enough until the plant has become fully established. To encourage bushing, cut off the growing points in winter or early spring and after flowering, cut the flowering stems down to the base so fresh stems may grow.