Acmadenia heterophylla easily adapts to growing in the garden where it requires full sun and well-drained soil. It will benefit from well prepared soil with compost and a thick layer of mulch. The plants also respond well to slow release fertilizer like 3:1:5. Although natural to limestone, Acmadenia heterophylla will also tolerate acidic soils. These are excellent plants for coastal gardens.

The plants can be propagated by seed or cuttings, but both require some skill. Fresh seed must be sown in autumn.

Cuttings have the advantage of producing a larger flowering plant faster than seedlings. Semi-hardwood cuttings, 50 to 70mm, are taken from the current year's growth (August to early October). Prepare cuttings by making a clean cut below the node and remove the third of the foliage. Dip the base of the cuttings in a rooting hormone such as Seradix 3. Firmly place cuttings in a medium of 50% bark and 50% polystyrene. Ideally these cuttings should now be placed in an well-aerated propagation unit with a bottom heat of 24-degree Celsius. Rooting occurs in 9 to 11 weeks. Carefully pot the rooted cuttings using a well-drained humus rich fynbos potting medium (2 parts leafmould, 1 part coarse sand). Plants will be ready for planting in 7 to 8 months. Feed regularly with a well balance nutrient. Yellow leaves can be treated with an application of iron chelate.