Large baobab trees with hollow stems have been used by people for centuries for various purposes including houses, prisons, pubs, storage barns, and even as bus stops! A big tree in the old Transvaal region is recorded as once being used as a dairy. Another tree near Leydsdorp was used as a bar (known as the Murchison Club) and utilized by prospectors and miners during the gold rush of the late 19th century. One such tree in the Caprivi Strip was converted into a toilet, complete with a flushing system.

Rainwater often collects in the clefts of the large branches, and travelers and local people often use this valuable source of water. It has been recorded that in some cases the centre of the tree is purposely hollowed out to serve as a reservoir for water during the rainy season. One such reservoir was recorded as holding 4 546 litres of water. A hole is drilled in the trunk and a plug inserted so that water can be easily retrieved by removing the plug. The roots of the baobab can also be tapped for water.

African honey bees (Apis mellifera) often utilize hollows in the baobab to make their hives. One can often see a 'ladder' of pegs hammered into the trunk which is used by seasonal honey harvesters to gain access to the hives.

The leaves are said to be rich in vitamin C, sugars, potassium tartrate, and calcium. They are cooked fresh as a vegetable or dried and crushed for later use by local people. The sprout of a young tree can be eaten like asparagus. The root of very young trees is also reputed to be edible. The seeds are also edible and can also be roasted for use as a coffee substitute. Caterpillars, which feed on the leaves, are collected and eaten by African people as an important source of protein. Wild animals eat the fallen leaves and fresh leaves are said to be good fodder for domestic animals. The fallen flowers are relished by wild animals and cattle alike. When the wood is chewed, it provides vital moisture to relieve thirst. Humans as well as certain animals eat it in times of drought.

There are many legends and superstitions surrounding the baobab tree. For example, it is believed that an elephant frightened the maternal ancestor of the baobab. In some parts the baobab is worshipped as a symbol of fertility. It is a belief among certain people that spirits inhabit the flowers of the baobab and that any person who picks a flower will be eaten by a lion. It is also believed that water in which the seeds have been soaked will offer protection against attack by crocodile, while sucking or eating the seeds may attract crocodiles. It is also believed that a man who drinks an infusion of the bark will become strong. In some areas a baby boy should be bathed in such a bark infusion, as this will make him strong; however, he should not be bathed for too long or he may become obese. It is also important that this water does not touch his head for this could cause it to swell. When inhabitants move from one area to another they often take seeds of the baobab with them, which they plant at their new homestead.

The bark on the lower part of the trunk often bears scars caused by local people who harvest and pound it to retrieve the strong fibre. The fibrous bark is used to make various useful items such as mats and ropes, fishing nets, fishing lines, sacks as well as clothing. Although the bark is often heavily stripped by people and elephants, these trees do not suffer as a normal tree would from ringbarking. Baobabs have the ability to simply continue growing and produce a new layer of bark. The wood of the baobab is soft, light yellow and spongy, and although it has been recorded as being used for making boxes, this does not seem to be a widely used practice.

Many references have made mention of the exceptional vitality of this tree, noting that even after the entire tree is cut down it simply resprouts from the root and continues to grow; the same is noted of trees which have been blown over in storms. Despite this remarkable vitality, when a tree dies it collapses into a heap of soggy, fibrous pulp. Stories exist of how such quickly decomposing trees spontaneously combust and get completely burnt up.

More than 260 years ago baobabs were apparently successfully grown in England and had reached heights of 5-6 m, but were all destroyed in the heavy frosts of 1740. Surprisingly few baobabs have found their way into cultivation, possibly due to their reputation of being exceptionally slow growing.

The baobab was declared a protected tree under the Forest Act in South Africa in 1941.

Determining the age of baobabs: Much speculation in literature over many years have made certain estimates of the age of certain large trees and their rate of growth. More recent work using carbon-dating techniques as well as the study of core samples showing growth rings, suggest that a tree with a diameter of 10 m may be as old as 2000 years.