Aloe africana is easily propagated from seed sown in spring or summer. The plants grow slowly and reach the flowering stage in 4 to 5 years. Sow in a sandy, well-drained potting soil in a warm, shady position in standard seed trays. Germination takes about three weeks. Cover with a thin layer of sand (1 to 2 mm), keep moist and the seedlings can be planted out in individual bags or containers as soon as they are large enough to handle.

Aloe africana thrives in coastal gardens but also as a pot or container plant. The plants prefer full sun and windy conditions. They are tolerant towards other plant species and often share their habitat with smaller succulent plants. Plants will benefit from compost or any organic feeding. The plants are not frost tolerant but can survive light frost. It thrives in a wide range of soil and even grows well in the winter rainfall Western Cape gardens where it should preferably be moistened during the dry summer months. The plants are fairly pest free, but may occasionally be attacked by the aloe snout weevil. Over-watering will also lead to fungal infections and rot.