Barleria randii can be propagated both by seed or cuttings.

Collect the seed as the capsules turn brown. Plant seeds in a mixture of equal parts of coarse river sand, good soil and compost (October to February). Place the seed tray in a shady spot and water once a week. Seed germination takes place after 6-10 days. Transplant the seedlings into containers when they are 100mm in size.

Barleria randii is difficult to grow from cuttings. Take semi-hardwood cuttings, 120mm in size, in summer and treat the cuttings with a hormone powder to stimulate root growth. Use a mixture of even parts soil and river sand as a growing medium. Put the container in a shady place and water twice a week. Transplant the rooted cuttings after 3-4 months in a good soil mixture. Expect a success rate of 20%.

Barleria randii thrives in deep sandy soils and does well in full sun. It is a slow grower and takes about two years to become established. There are no specific pests and diseases affecting this species.