Horticulturally the plants are very popular in rock gardens, on rocky embankments, hanging baskets, and as perennial container plants. They make beautiful displays when planted en masse in shade or semi-shade.

It is easy to grow plants vegetatively as well as sexually. For quick results, leaf or stem cuttings can be made from mature plants. Cuttings can be made throughout the year and root readily in a well-drained medium. Many rooted plants will form from the mother plant in the garden. It may therefore be easier to transplant young plants as they root from leaves that have fallen off in the garden.

The seeds are very fine and must be harvested as soon as the inflorescence turns brown as the fruit ripens. Seeds should be sown on a damp, sandy medium and be kept shaded and moist while cuttings are inserted into coarse river sand and later transplanted into ordinary garden soil. Other shade and semi-shade plants that do well with Crassula multicava include Portulacaria afra var. prostrata, Plectranthus saccatus, P. ciliatus, P. zuluensis, Asparagus densiflorus, A. kraussiana, Crassula spathulata, Impatiens hochstetteri, Begonia sonderiana, B. dregei and B. sutherlandii, Clivia miniata, C. gardenii, C. nobilis, Ledebouria petiolata and Gasteria spp.