Crassula rubricaulis is easy to grow. It requires a position in sun or semi-shade with well-drained soil. The more shade it receives, the less strongly it develops red colouration in its stems and leaf margins. Feed with plenty of well-rotted compost. It does not need a lot of water, but should receive about weekly watering to perform at its best, and in the winter-rainfall Western Cape it needs occasional watering during summer as well. This is an excellent water-wise shrublet, well-suited to rockeries, terrace walls, fynbos gardens, and coastal gardens. It does well in containers on a sunny stoep, and can be grown on a windowsill or in bright light indoors.

Propagate Crassula rubricaulis by seed or cuttings. Sow seed in autumn or spring to early summer. Sow thinly on the surface of a well-drained, sterile medium or mix the seeds with coarse sand and sprinkle it in a thin layer on the surface. Keep moist and well ventilated. Pot up into individual containers when the seedlings are large enough to handle. Cuttings can be taken at any time of the year and they root easily without the need for misting or bottom heat. Root the cuttings in a well-drained medium in a cold-frame, or plant them directly where they are intended to grow, and keep moist but not wet. This species roots itself as it spreads, and rooted stems can be removed and replanted in a new position. In the Western Cape direct transplanting is best done in autumn to coincide with the rainy season, or the young plants must be watered regularly until established.