The Orange River lily is easily propagated by seed and is quick growing, reaching flowering age after three to four years. The large irregularly shaped seed can be sown in deep trays or directly into the garden where they should be just covered and watered well. Seed viability is short-lived, so sow them as soon as possible. The bulblets are susceptible to attack by Amaryllis caterpillar which will also attack adult plants and can be responsible for much damage or even the demise of the plant, especially young bulbs.

Adult plants are best grown in deep soils that receive and hold a lot of water during the growing season. They can be transplanted but ideally should be left to grow in the same place without disturbance. They require full sun and plenty of water although they can endure periods of drought during their growing season without adverse effects. They also make good container plants. In nature they survive summer temeratures of up to 40°C and cold dry winters of -8°C.