Grow Othonna triplinervia in a sunny position in well-drained soil. It is well suited to rocky sites, rockeries or retaining walls and withstands high rainfall in winter or summer, provided the soil does not get waterlogged. It is water-wise when established. It is probably not hardy to frost.

Othonna triplinervia can be propagated by both seed and cuttings, however, the most preferred method is by means of cuttings, as it allows one to have a mature plant within 4–6 weeks, whereas by seed, it would take three times the period to get seedlings to be of size ready for transplanting.

Sow seeds during late winter or early spring in a well-drained medium consisting of equal amounts of river sand, vermiculite and sifted bark. When sowing seeds, they need to be spread across the medium and lightly covered with sifted bark or sand. When the first true leaves appear, they can be transplanted into small plugs, pots or bags, where they can grow until they are big enough for larger pots. To avoid any pathogens, make use of a soil drenching fungicide when watering both seed and cuttings.

Cuttings can be made throughout the year, but does well when done in hotter drier months, as they often rot when kept in a soggy medium for too long. Cuttings can start from 100–300 mm or even larger, depending on one’s preference. The younger the material the easier or quicker it roots with the aid of an appropriate hormone powder or solution. They do not need a mist unit, preferably place them in a cold frame or a similar controlled environment and ensure that the cutting medium is kept moist, plants are not in direct sunlight, and the air is not hot or dry. As soon as the cuttings have rooted, they can be transplanted into pots or bags, proportional to that of the cuttings, in a medium consisting of 50% river sand, 25% well-rotted compost and 25% sifted bark. Plants are self-sufficient but benefit from a drench of high nitrogen liquid fertilizer.