Pachypodium bispinosum is rarely seen in gardens, but is not so difficult to cultivate and it is drought resistant. Plant it in well-drained soil, avoid waterlogged conditions and water sparingly in summer. Do not water in winter. Your watering program might vary depending on the stages of growth and changing temperatures. The plant is intolerant to cold and frost and it should be totally dry in winter. If this plant is cultivated under less than ideal conditions or allowed to get too wet in winter, it is liable to rot.

When growing in a container, the soil medium must be sandy and mixed well to allow for good drainage and prevent root rot, as the plant is likely to suffer from it. Use a large pot with holes to drain excess water. Water regularly during the summer growing season from September to April, water every day during the vegetative period, checking if the soil is completely dry before watering. During the winter season (May to September) the plant enters dormancy and watering may be stopped.

The plant can be fertilised once a month during the growing season with a fertiliser specifically for succulent plants, fertilization must be stopped in winter.

Propagation of this plant can be done by seeds and cuttings. Take stem cuttings in spring. Take 10 to 22 cm long cuttings from the younger branches and let them dry out for a couple of days until a callus forms on the surface. Dust the cut end with rooting hormone and place the cutting in your rooting medium mixture and keep in a warm and moist in a semi-shaded position. For a successful propagation you can do a lot of cuttings at the same time.

Sow fresh seeds in sandy loam soil in early summer and keep warm and moist, in a humid environment.

Pests such as red spiders and mealybugs may attack at times but can be controlled by an appropriate pesticide product.