Pachypodium saundersii is best propagated from seeds. Harvest fresh seeds and propagate as soon as possible, so they do not lose their viability. Remove the parachute of silky hairs, sow the seeds about 5 mm deep in a light, sandy medium such as a mixture of 4 parts fine and 4 parts coarse river sand, 1 part sieved compost, 1 part perlite and 1 part vermiculite. Keep the medium moist and warm to ensure rapid germination of the seeds, they require a warm environment of 27-35°C. Seeds take up to 6 weeks to germinate, if there is no germination they are regarded as not viable.

Propagate vegetatively through tip cuttings taken in spring or summer, allow the cut ends to dry for a week or so to form a callus and treat the fresh cut with a fungicide or flowers of sulphur to prevent rotting. Treat the cut end with rooting hormone and plant the cuttings in the same medium as that used for sowing seeds. Place the cuttings in a warm, semi-shaded, well-ventilated environment until rooted.

Best for warm, frost-free gardens with a cool, dry winter. Plant in well-drained soil in full sun or semi-shade. Allow the plants to remain dry during the winter dormant period. Take care not to overwater.