Plectranthus mzimvubuensis is easy to propagate through asexual propagation. Take cuttings from the mother plant, whether it is stem cuttings, tip cuttings or heel cuttings. Follow the general procedure for making cuttings, cut below a node and remove two thirds of the leaves. You can use rooting hormone for soft cuttings to help with quicker rooting, but Plectranthus species can root without the use of a rooting hormone. The stem of Plectranthus mzimvubuensis is semi succulent and sensitive when cut, therefore, sterilize your cutting tool when making cuttings, to eliminate infections and ensure a high survival rate of your cuttings. A fast-draining rooting medium mix of sand, fine-milled bark or vermiculite is used at Kirstenbosch NBG when growing the cuttings. Place the cuttings tray in a well-ventilated, shaded location and water once a day or more if necessary during extremely hot weather. Roots will emerge after 3 to 4 weeks, at which point the cuttings can be transplanted into pots containing a potting mix of sand, fine-milled bark and compost. This species of Plectranthus is also propagated through division.

Plectranthus is seldom propagated from seeds because cuttings grow very easily and seed-grown plants take longer to grow. The seeds are sown in early summer, in a mix of sand, fine-milled bark and compost, then covered with a thin layer of fine-milled bark. Water consistently until the seedlings are ready to be potted.

Plectranthus mzimvubuensis is shade loving and grows best in a well-drained soil. Pruning is done yearly, just after flowering is finished. The plant is cut back to reduce the height and to promote the growth of new healthy shoots. Old, dead branches are cut off and any pests or diseased branches removed. Water adequately and take care not to over water as the stems of Plectranthus will rot in soggy, poorly drained soil. In the garden, Plectranthus, should be watered once or twice a week, depending on the weather. When growing Plectranthus in the garden, one needs to consider the plant’s height and width. A spacing of 60 cm is recommended when mass planting to get the best effect when in flower.

Plectranthus species are not highly infested with pests, but with some species, like Plectranthus oertendahlii, the roots are attacked by microscopic eelworm which prevents the plant from taking up water and nutrients. Infected plants should be removed and the soil replaced. A common pest is the mealybug which can be seen behind the leaves and on the stems, especially on the juvenile plants. Common fungal diseases are rust and blight and root rot can also occur especially when cuttings or plants are over watered. Good nursery hygiene should prevent these problems.