Pouzolzia mixta is a small tree or multi-stemmed shrub growing up to 4 m high. The bark is dark reddish-brown and smooth; branchlets have a velvety surface. Watery latex present.

The leaves are simple, spirally arranged and ovate with a tapering apex and lobed base, 3-veined from the base with smooth margins. The leaves have contrasting upper and lower surfaces, the upper surface dark green and the lower surface silvery white-felted. Leaves tend to stick together and to clothing.

The flowers are small and greenish with separate male and female flowers on the same plant. They grow in dense clusters in the axils of leaves. The fruit is a very small nut enclosed in the remains of the flower.