Sow seeds in late summer to autumn (March-April), in a well-draining, growing medium. Cover the seeds lightly with a layer of sand or fine bark, and water thoroughly. Keep the medium moist and do not allow to dry out completely. Seeds will germinate in one to two weeks. Seedlings will be ready for transplanting into the garden at four to six weeks.

Plant Senecio littoreus in groups or clumps to bring spring colour to the mixed border, mass plant as a bedding plant, plant in pockets in a rockery, or grow in containers or window boxes. It is also suitable for coastal gardens. Plant it in sandy areas or on a sloped area, which should allow for good drainage.

Senecio littoreus will also perform well planted among companion plants. Combine them with other annuals such as: Felicia tenella, F. heterophylla and F dubia, Arctotis hirsuta and A. fastuosa, Dimorphotheca pluvialis and D. sinuata, Nemesia strumosa, Senecio arenarius and S. elegans, and/or herbaceous perennials and woody shrubs including: Arctotis acaulis, Arctotheca calendula, Cotyledon orbiculata, Lampranthus aureus, species of Carpobrotus, Chrysanthemoides monilifera subsp monilifera and Pelargonium fulgidum, P. capitatum, P. cucullatum and P. betulinum.