The bottlebrush spiderhead requires the following in a fynbos garden: well-drained granitic soil that, once planted, is disturbed as little as possible, good air circulation and direct sunlight for most of the day. If drainage is a problem in your garden, try to build a slope and plant your fynbos along it. At Kirstenbosch, plants thrive along the higher slopes in the restio garden where soils have a granitic base. In the protea garden they do not grow as well, as the soil has a sandstone base.

Plants are prone to attack from fungi, specifically Phytopthora which causes root rot. This disease is exacerbated by applying too much water during warm weather.

Serruria brownii thrives in a winter-rainfall environment where summers are hot and dry. Plant young plants into your garden during late autumn or at the start of the rainy season. Additional water can be given during their first summer although if you have planted at the correct time, this is not necessary. Apply a thick layer of mulch to keep the soil cool and moist.

Serrurias do not require large amounts of feeding. Incorporate a small amount of well-rotted compost at planting and feed twice a year with a fertilizer specifically formulated for fynbos plants.

Serruria brownii can be propagated from cuttings or seed. Cuttings have a much higher success rate and are more freely available than seeds. Make cuttings from December to March (summer to autumn). The cuttings should be taken from the current season's growth and measure 30-70mm long. Dip the cuttings into a rooting hormone solution or hormone powder and plant into a medium of 50% polystyrene and 50% finely milled bark. Place in a growing house with bottom heat (25°C) and intermittent mist. Once the roots are well developed, remove from the mist unit and harden off for three weeks. Plant the cuttings into small pots using a fynbos potting mix and grow on until ready to plant into the garden.