Struthiola dodecandra can be propagated both by seeds and cuttings but the best method is cuttings. Collect cuttings from healthy mother stock in autumn or spring, plant in well-aerated growing medium and place on a heated bench, this will help speed up rooting and reduce the number of weeks needed for rooting. After about 6 weeks,  transplant the rooted cuttings into planting bags and care for them until they are ready and strong enough to be planted out into the garden during winter months. Plant them in full sun, in moist soil or in a wetland area.

Propagation by seeds is challenging because the seeds disperse quickly. To harvest seeds, the plants should be monitored and the flowering stems carefully covered with mesh bags that will catch the seeds as they disperse and they can thus be collected when ready. Sow seeds in the autumn months, preferably April, and treat the seeds with smoke to ensure a better germination rate.