As natural populations of Monilaria chrysoleuca are found on the highly-specific quartzitic soils of the Knersvlakte, the species is not as easy to grow as many other collectable succulents and require a moderate level of maintenance.

The cuttings of Monilaria chrysoleuca are difficult to root, so propagation is usually done from seed. The most efficient way to collect the seeds is to allow the capsules to dry on the plant. Once dry, break the capsules open and gather the seeds. The best time to sow the seed is in autumn. Monilaria chrysoleuca grows most successfully when potted in sandy, well-drained soils and placed in full-sun. Planting the seeds into a pot with sufficient drainage is very important as the species is known to be susceptible to root rot.

Restrict watering in summer, as the species naturally occur in winter rainfall areas and only once the new leaves appear in autumn, should you water regularly. Do not over-water the plants, as they are adapted to arid conditions. Possible pests of Monilaria chrysoleuca include mealy bug and scale on the leaves. Although plants of M. chrysoleuca go into dormancy during the summer months, the unusual stems are still striking and the grower is rewarded during the winter months with 2 leaf types, as well as a display of large flowers. M. chrysoleuca can be grown together in a large pot with a range of other succulent species, creating a year-round attractive pot.