Nerine masoniorum is the most easily cultivated of all the dwarf nerines and requires a free-draining medium such as equal parts of river sand, loam, and finely sifted compost. The bulbs should be planted with the top of the neck just above soil level, and once planted should be left undisturbed for at least four years, as best flowering results are always obtained from well-established plants. The plants prefer full sun. They will also flower well in light shade, but under the latter conditions the flower stems lack the strength of sun-grown specimens, and tend to fall over.

N. masoniorum makes an excellent container subject and is also a most valuable bedding plant where it is suited to planting as a thick border to larger annuals and perennials such as Senecio elegans and Lobelia valida.

Plants require regular watering during the summer months (a good soaking once per week if natural precipitation is lacking). They can be dried off completely in winter but do not object to winter rainfall, provided the soil medium has excellent drainage.

Propagation is easy and is either by separation of offsets (daughter bulbs) from the mother bulb, or by seed. Separation is best carried out in early spring just as warmer weather sets in and new leaves begin to develop. Carefully lift thick clumps with a large garden fork, shake off excess soil, and then separate daughter bulbs by carefully tugging them away from the mother bulb. Do not forcibly break the bulbs away as this will damage the bulbs' basal plate. Daughter bulbs that do not come away easily by careful tugging are not yet ready for separation. Prevent the perennial, fleshy roots from drying out by replanting separated daughter bulbs as soon as possible, at a distance of 2-3 cm apart.

Seeds are produced in profusion in March in the Southern Hemisphere. They are fleshy and water-rich, and do not undergo a dormant period, but germinate almost immediately they become ripe. Sow the seeds in seed trays as soon as they are easily detached from the dry flower capsules, evenly sprinkling them over the surface, and covering with 5 mm of sowing medium. Seed trays are best placed in semi-shade until seedlings are growing strongly, after which they can gradually be moved to full sun. Germination is rapid and the young plant rapidly forms a bulb that will reach flowering stage in two to three years, under ideal conditions.

The main pest affecting N. masoniorum is the lily borer, also known as the amaryllis caterpillar (Brithys crinii). The night-flying moth lays its eggs on developing flowerbuds and along flower stems, especially during the hot summer months. The voracious caterpillars rapidly bore into the tissue and can cause collapse of flowerstems in as little as two to three days. In highly susceptible areas in parts of Gauteng, KwaZulu-Natal and Western Cape, this pest can be treated preventatively by spraying with carbaryl every two weeks. Poor drainage of the growing medium leads to fungal rotting of the bulb roots which affects flowering performance, but seldom causes death of the bulb.