Plectranthus zuluensis 'Lupatana' is best propagated from tip cuttings, from spring to summer. Cuttings can be treated with a rooting hormone for fast rooting. Cuttings can be placed in sand or any other similar rooting medium that is well-drained and allows rapid air flow. Intermittent mist-spray facilities will hasten root development and reduce excessive transpiration. Alternatively one can root the cutting in humus-rich, well-drained soil in a shaded area. Once established they need little watering. Prune annually after flowering to remove dead or diseased plant material. Pot plants should be watered twice a week and should be given a liquid fertilizer feed every fortnight.

As with most Plectranthus species, soil-living eelworms which infest plant roots can be a problem. Take cuttings of the plants and remove and burn roots of affected plants. Nematicides are available commercially, but handle these with care as they are usually highly poisonous. Most insects avoid Plectranthus plants, possibly because the high essential oil content of the leaves makes them unpalatable. Fungal diseases such as rust and blight occasionally attack the plants, but can be controlled by spraying with appropriate fungicides.