Podalyria sericea grows best in full sun, and prefers well-drained, well-composted, acidic loam soils. It is easy to grow and has a moderate growth rate. A good garden subject and water-wise once established, it does well combined with other drought tolerant plants. In mixed fynbos beds it is best grown in groups, planted close together for a mass effect where its silvery foliage provides a wonderful contrast against the green of the other shrubs. Used in a rock garden, it makes a striking specimen plant, or can be an unusual container plant.

In summer rainfall areas it must be watered well in autumn and winter. It does not thrive in alkaline soils. As it is from a frost-free climate, it does not tolerate frost, so it will need protection when grown in gardens where severe frost may occur.

As with most Fabaceae, growing Podalyria sericea is quite difficult from cuttings. It is best grown from seed sown in autumn or spring. Seeds germinate easily. Soaking seeds in hot water and treating with a fungicide that combats pre-and post-emergence damping off will increase the success of germination. Sow 1-2 mm deep in sandy, well-drained potting soil. Seed germinates in approximately two weeks. After germination, the seedlings should be potted up into individual bags/pots as soon as the first pair of true leaves appears, taking care to minimize root disturbance. Protect young plants from frost.