Sansevieria pearsonii is propagated by cuttings or by division, at any time, or by seed sown in spring or summer. The cuttings should be at least 10 cm long and inserted in moist sand. It is a slow process, but a rhizome will emerge at the cut edge of the leaf. Seeds are short-lived and should be planted as soon as they are ripe. Clean off the flesh and sow in well-drained (sandy) soil in late spring or early summer, press the seeds just under the surface of the soil, keep warm and moist but not wet.

Plant in well-drained soil in semi-shade or light shade. It is a low maintenance plant and makes a great container plant. The plants are very drought tolerant, and can thrive with minimal watering, and need only be watered weekly during the growing season and once per month or not at all during the winter resting period. They can be fertilized once during the growing season, with a balanced fertilizer, for best performance.