Aloe boylei can be easily propagated by seeds or by division.

Collect seeds when the capsules are dry and begin to split open. Remove the seeds by hand and sow them in spring or summer, when temperatures are warm. Fill a seedling tray with a mixture of potting soil and washed river sand, level the surface, and scatter the seeds evenly. Cover the seeds lightly with a thin layer of the growth medium. Place the tray in a warm raised bed in a glasshouse or under shade netting. Water gently using a fine mist spray, keeping the soil slightly moist but not waterlogged. Germination typically occurs within four weeks. Transplant seedlings into individual pots when they reach 5–10 cm in height, keeping them under an 80% shade netting. Gradually expose the plants to full sunlight, reducing watering slightly to encourage strong root development.

The best time to propagate Aloe boylei by division is during its active growing season, in spring or early summer, as this allows the plant to recover quickly from the stress of separation. Carefully dig up a mature plant and separate the small offshoot from the main clump. Plant the offshoot in a mixture of potting soil and washed river sand in an individual pot or plant bag. Place under 80% shade netting and water lightly until established. Offshoots can be planted in the ground after two years.

Aloe boylei thrives in partly shaded locations with well-drained loamy soil. An organic fertilizer can be applied in summer to promote healthy growth. It is a fast-growing plant that can tolerate a few hours of direct sun, but excessive sunlight may stress the plant and burn the leaves. Water moderately, allowing the soil to dry out completely between watering. During the active growing season in spring and summer, water slightly more frequently, and reduce watering in autumn and winter when the plant is resting. Remove dead, damaged, or dry leaves in summer using sharp, clean pruning shears, cutting as close as possible to the base of the rosette.

Aloe boylei is suitable for mixed flower beds, where it can be used as a border plant at the edge of the bed, and it performs well in containers. It can be planted alongside species such as Callilepis laureola and Aloe simii.

Mealybugs and scale insects may attack Aloe boylei, but these pests can be effectively controlled with pesticides. Root rot is a common disease affecting succulents, including Aloe boylei, when overwatered; fungicides can manage this condition effectively.