This shrub is quite challenging to grow, and the best results are achieved by copying its natural habitat requirements, just like most Amphithalea and Liparia species. It is fond of damp, acidic soils and needs lots of water in the winter months. It is best to grow it in flower beds in full sun or half-day shade with larger plants protecting it. Feed with a slow-release organic fertilizer and apply mulch of well-rotted compost in spring and autumn. As fire is suspected to rejuvenate older plants, mimic this by cutting the old woody stems, in the summer months, back to the rootstock and leave a few younger stems to sustain the plant.

Ampithalea tomentosa can be propagated by both seeds and cuttings. Numerous seed pretreatments are recommended to enhance germination outcomes. Subsequently after matured seeds which are naturally dispersed are collected, it is recommended to dry the seeds in silica at 18°C and 15% relative humidity for a few months. Prior to sowing, seeds must be scarified to break dormancy by directly removing the seed coat. This can be achieved by either using sandpaper to remove each seed or by using a scalpel or blade to remove the seed coat. Scientists and researchers at Kirstenbosch National Botanical Garden most often smoke the seeds using the smoke tent method or they soak seeds in smoke water solution overnight for 23-48 hours prior to sowing. A viability test using a Tetrazolium Staining Test, Seed float test and testing seed vigour using Accelerated Aging are recommended.

Seeds should be sown during the cool periods to achieve optimal conditions, preferably in autumn, late spring, or early summer. Next seeds must be sown in well-draining soil medium, preferably sandy, and kept at an optimum temperature. Germination can take up to 4-5 weeks or less, monitoring is recommended as ungerminated seeds can get mouldy.

Semi-hardwood cuttings can be taken in late summer, autumn, and spring. Disease-free and insect-free plant material should be selected after flowering. Thin and new shoots at the base should always be first choice for taking propagating material from. The appropriate rooting hormone or root stimulants are required to stimulate and accelerate the rooting process. Overwatering and areas with high relative humidity are not ideal to place cuttings as they may cause the cuttings to suffer from root rot or other fungal diseases. Moreover, in the early stages of taking cuttings, direct sunlight should be avoided to minimize plant shock and fatality.