Crassula sarmentosa is propagated by leaf cuttings or by division. To propagate by leafe cuttings, carefully detach the whole leaf, with its base intact, from the mother plant. Place the single leaves of  in shallow planting trays or small containers filled with potting mix for succulent plants (well-drained). Insert the base of the leaf at an acute angle, 2-3 mm below the soil surface, with the leaves curving upward, allowing for the baby plant to root on the side. The best potting mix would be coarse river sand (for drainage), mixed with organic elements comprising of bark and well-rotted compost to provide nutrients and perlite (for aeration). Ideally this should be in the ratio of 2 parts sand to 2 parts of potting soil to 1 part of perlite (2:2:1). Rooting occurs after 2-3 weeks and when the roots have reached 4-5 cm they can be planted out.

To propagate from stem cuttings, cut stem tips with a sterilized secateur. For a higher success rate cut a complete stem to obtain multiple cuttings. Keep 2 leaves at the top of 5-7 cm long cuttings and remove the rest of the leaves (M. Ntombela pers comm 2023). Use a rooting hormone powder with Indolebutyric acid (IBA) for the stem cuttings to absorb auxins and to accelerate root  formation. Moisten the base of the cutting stems at the node and insert the stem cuttings so that the node is completely covered by the soil. Place several cuttings equally spaced in one shallow planting tray and place in a shade house, with s day time temperature of 23 -25 0C. Rooting from stem tips is usually faster than leaf cuttings. Water only when the roots have formed.

Grow Crassula sarmentosa in full sun, or semi-shade, or in indirect sunlight all day long or direct sun for up to 6 hours a day. Plants thrive in  sandy well-drained soils among rocks when they are planted outdoors and in a well-drained potting soil medium for succulent plants when planting in containers. Infrequent watering is preferable, allowing for the soil to dry between each watering.

Like most succulents, Crassula sarmentosa needs well-drained soil, and a well-lit, well-ventilated position and does not like having wet roots. Since they are drought tolerant and frost tolerant, with a low water demand, Crassula sarmentosa are well suited to a xerophytic garden. A fertilizer applied occasionally in the growing season is sufficient . Prune the tips of the new growth stems, to encourage Crassula sarmentosa to develop a more dense and rounded shape.

Crassula sarmentosa is widely used as a groundcover or filler plant in landscape applications. Since it is dense and well-rounded when pruned, they are suitable for interplanting in rock gardens and amongst taller shrubs and they are well-suited as a short evergreen border plant and pathway edging plants. Crassula sarmentosa makes perfect hanging baskets in confined spaces as well as feature container plants on shady or sunny patios.

Perennial daisy bushes such as Dimorphotheca ecklonis, D. fruticosa and D. jucunda (all previously included in Osteospermum) and their many hybrids and cultivars still sold as Osteospermum or African Daisy are recommended companion plants, having similar water, sunlight and fertilizer requirements. These shrubby perennials provide a show of colourful petals against the backdrop of the dark green Crassula sarmentosa leaves. Adding white or coloured pebbles between individual Crassula sarmentosa plants in smaller garden beds or granite stones in larger landscape areas create contrasting colour and textural effects. Crassula sarmentosa is popular with water-wise gardeners along the east coast of southern Africa that wish to attract bees and butterflies to the garden.  

Crassula sarmentosa is susceptible to mealy bugs and spider mites. Spray a non-chemical deterrent, such as neem oil, to keep these pests away. Fungi from the genus Rhizoctonia can cause leaf spots and root rot. Spray the soil around the plants, with chemicals containing copper compounds and mancozeb (triazole) to kill  the fungus.