Erica ampullacea is not often seen in cultivation. It flourishes in full sunlight in a well-ventilated area, in acidic, well-drained soils, particularly those with a sandy or peaty composition, and requires minimal maintenance and has low nutrient needs. The best time to plant is in autumn, with a spacing of about 30 cm between individual plants to allow for adequate growth. Propagation is achieved through seeds or cuttings.

The water requirements of E. ampullacea are moderate. It thrives in well-drained, sandy soils, and overwatering should be avoided to prevent waterlogging. Planting on a slope can also prevent waterlogging. Irrigation is recommended once or twice per week, depending on climatic conditions. Apply well-rotted compost as a mulch in autumn and spring – this provides nutrients, keeps the roots cool and suppresses weed growth. One annual application of a slow-release fertilizer specifically formulated for acid-loving plants, applied in autumn, is sufficient to support growth. Excessive fertilization should be avoided, as it may lead to root damage or nutrient toxicity. Pinching the tips of young plants will result in more bushy, floriferous growth, but regular pruning is not needed for E. ampullacea; although occasional trimming can stimulate denser growth and enhance flowering. Pruning is should take place just before new growth in late summer or autumn.

Erica ampullacea can be propagated by seeds or cuttings. Propagation by seed is the most common method. Mature seeds should be collected and sown in late summer to autumn in a well-draining medium such as one composed of peat and sand. Germination usually occurs within 2–3 weeks under ideal conditions. Cuttings can also be an effective propagation method, especially if there are stems without flowering buds. Cuttings should be taken in spring or autumn. Semi-hardwood tip or heel cuttings 10–15 cm in length should be taken, with the lower 5 cm of foliage removed. The cuttings should be treated with a rooting hormone, and planted in a well-draining medium, and placed in a misting unit on heated benches, under indirect light so that rooting can take place.

One of the significant diseases that affect this species is Phytophthora root rot. This disease is caused by the soil-borne pathogen Phytophthora cinnamomi, which leads to wilting and plant death. To avoid infection, plant in well-draining soils, keep root-disturbance to a minimum and do not over water. Removal of infected plants and improvement of soil drainage are essential for management.