This species is easily cultivated from seed and cuttings. Seeds are collected as the fruit starts to split open – pick the seeds off from their parachute-like tuft of hairs before it opens. The seeds are best sown fresh, but they can be stored for about a year under normal room conditions. Use wood-ash from a fire mixed with the seed to prevent attack by insects. Seed in South Africa ripens naturally toward the end of the winter (August), just before the spring rains start.

Sow fresh seed in spring when temperatures are warm. Fill seed-trays with compost and soil mixed in even amounts. Use a mixture of 50% seedling mix (or peat-moss or vermiculite) and 50% river sand. Sow seed and lightly cover with sand. Keep in a warm place that is moist at all times. Seedlings will germinate after ± 2(3-6) weeks. After germination protect the young plants from wind and sun and continue to water regularly – do not let the soil dry out completely. Seedlings grow rapidly in the growing season – up to 30 cm every 3-4 days.

Mondia whitei is easy to grow and propagate from cuttings. Collect cuttings in the morning or on cool days, preferably from spring to late summer. Prepare cuttings measuring approximately 5–10 cm in length and treat them with a rooting hormone to stimulate root formation. Place the cuttings in a well-drained growing medium consisting of coarse river sand and milled bark and place them in a mist house. Monitor the cuttings regularly and remove any dead or fallen leaves to prevent disease. Rooting occurs within two weeks. Allow the cuttings to remain in the propagation medium for about one month to ensure adequate root development before potting.

The cuttings grow rapidly, and plants can reach approximately 1 m in height within three months. When long stems develop, train them onto supports early to prevent tangling. When plants reach about 15 cm in height, re-pot into larger bags or pots, or plant directly into the garden if possible. Ensure that plants are given sufficient growing space for healthy growth.

In the garden, plants are established from seed under the tree canopy and create a very pleasing display of the species in the garden. The plants that receive support in the garden climb much higher than those without support, with some plants observed to reach over 8 m tall in the garden. Plants that do not find suitable support are unable to climb, as their new growth requires a structure to attach onto in order to grow upwards.

Suitable areas to grow plants are usually restricted to lower,  frost-free elevations. The maroon umbrella-shaped flowers splashed with yellow-green edging on the corolla lobes are arranged in attractive clusters. The coconut-scent encourages visiting insect pollinators, which are especially active in the early morning and evening. After fertilization the horned pods (follicles/fruits) develop which can reach the size of a man's outstretched hand. Undisturbed, these plants are remarkably long-lived. One specimen has been known to grow on the veranda of a hotel for 50 years.

Plants are commercially available from various nurseries at reasonable prices. Climate dictates the rate of growth. Make sure that the plants have enough room to grow.