Nerine gracilis is best propagated through seeds. Seeds are fleshy, they take 3-4 weeks to mature and must be sown immediately when ripe, when they detach easily from the capsules. A well-drained soil mixture of 70% potting mix and 30% sand, or equal parts of river sand and silica sand with finely sifted compost added is recommended to grow nerines from seeds. Use a deep seed tray, sprinkle the seeds evenly over the surface and cover them with a thin layer of the same soil mixture and water well with a fine rose. The seeds root themselves quickly and the small bulbs take 2-3 weeks to develop but they are very vulnerable to dry weather at this time so avoid dry conditions during this stage. The young plants should be left in the seed tray for at least 2 years and potted up at the beginning of summer.

Nerine gracilis can also be propagated by removing offsets from the mature bulb in late spring, just before or at the beginning of the growing season. The offsets are ready to be removed if they are easily separated from the mature bulb and must not be forcibly broken off. The separated offsets must be replanted immediately.

Because this is a dwarf species, it is best grown in containers, planted close together and massed for best effect. Grow Nerine gracilis in free-draining sandy soil with the addition of a little fine-sifted compost. Place them in full sun. During the summer season, give regular heavy watering every 7 to 10 days. In temperate climates or in the greenouse plants will remain evergreen but in cold climates it should be allowed to go dormant during winter and the bulbs should be left dry. It is a fast growing plant which thrives under controlled climate conditions or in a greenhouse. They are best planted in mixed flower beds, and are suitable for containers. When planting in plastic pots, it is recommended to use the 20 cm size. Plant the bulbs with the top of the neck resting at the soil level or just above it. It flowers in late summer to early autumn.

Nerine gracilis plants are susceptible to Mealy Bug infestation and Narcissus Bulb Flies. They should be treated frequently, especially in the beginning of the growing season, with systemic insecticide such as Imidacloprid. They are also vulnerable to attack from Amaryllis Caterpillar that eats all parts of the plant and the seeds. Nerines are poisonous to animals (pets) when eaten, and need to planted in areas where pets cannot access them.