All Nerine species can be successfully cultivated in containers. N. krigei is well suited to rockery pockets, whereas finer dwarf species, are best grown in pots. For best effect, Nerine krigei must be planted in groups, or else scatter them amongst wetland grass to obtain pink splashes in summer.

Nerine krigei is an easily grown species that will grow and flower well in most free-draining garden soils to which organic matter, such as well decomposed compost, has been added. A suggested mixture when growing Nerine in containers, is equal parts of river sand, silica sand and finely sifted compost. Bulbs of N. krigei should be planted with the comparatively long neck fully covered with soil, in order for the top of the neck to rest just below the surface.

As the bulbs have fleshy roots which resent disturbance after planting, they should be left in the same position for many years, until they eventually become too overcrowded and may need to be lifted and divided. Mature bulbs freely produce offsets and propagate easily from seed. They may reach flowering size within 3 to 4 years. Seeds can be sown in deep seed trays in a well-drained seedling mixture, such as equal parts river sand, silica sand and finely sifted compost. Spread the seeds evenly, press them lightly into the mixture and cover with a thin layer of the same mixture, and water well.

N. krigei plants are susceptible to mealy bug and lily borer, where the tiny caterpillars can bore into leaf, stem or flowering tissue; they may eventually bore into and consume the bulb itself, causing the collapse and death of the whole plant. If left unattended slugs and snails can also cause damage to the plant and may transmit viral diseases.

A full sun position is recommended and regular deep watering during the summer growing period, is required. It is recommended that bulbs should be kept dry during the winter dormant period; this hardy species can withstand cold and frost in winter, but require sufficient moisture during summer for it to flower freely.