Although very attractive, this species can be difficult to get to flower in cultivation. Plants can be grown in deep pots or in a well-drained rockery in suitable climates. These plants require very high summer temperatures and a completely dry winter period to thrive. Bulbs should be planted with their necks just below soil level. Plant in a sandy medium with a little compost and water heavily in summer while the plant is growing, but allow the soil to dry out between waterings.

Nerine laticoma does not produce offsets, but is easily grown from seed. When the seed is ripe, sow it in deep seed trays in a sandy medium. Just cover the seed. Leave the seedlings in the trays for at least two seasons, after which they can be grown on in larger containers, or planted out in the garden. The broad-leafed N. laticoma takes at least five years to flower for the first time when grown from seed.

Watch out for attacks by the amaryllis lily borer and mealy bugs. Slugs and snails can do great damage to the leaves, and are responsible for transmitting viral disease. Remove the pests by hand or use a bait or repellent such as broken eggshells or tobacco dust in a ring around the base of the plants. Thrips, a minute, narrow, sucking insect can also attack the plant. They are most often found on the undersides of the leaves, resulting in characteristic white streaks. Control severe infestations with a pesticide spray.