The cultivation of Nerine ridleyi is not too difficult, however flowering is highly erratic, and the species is thus suited to the bulb specialist rather than to the general gardener. It is best grown in deep containers in an acidic, well-drained mixture  containing washed river sand and finely sifted, acid compost or finely milled bark. In cold climates, terracotta pots are more suitable, but in warm parts, plastic pots are preferable. Plant the bulbs in late summer or early autumn, with the necks well above soil level, and apply a heavy water drench. Place the container under cover of a roof, where it will have a sheltered, semi-shaded and well-ventilated environment. Flower buds and/or a new set of leaves may emerge within a few weeks of watering. Once the leaves emerge, water the bulbs heavily about once every 10 days until early summer, whereafter, reduce watering to about once per month. Once the leaves have started to die back, withhold watering until late summer/early autumn.

Nerine ridleyi is propagated by offsets or by seed. Separate offsets from the mother bulbs in late summer or early autumn, and replant immediately. As seed viability is limited, sow seed in containers as soon as it is ripe, in a similar medium recommended for adult bulbs. Extreme patience is required in raising seedlings to flowering size, as this may take six or more years to achieve.

The bulbs are subject to attack by mealy bugs at any time of year, and snails occasionally feed on the leaves, and can transfer viral disease. The bulbs and roots are highly susceptible to fungal disease, usually caused by an insufficiently well-drained growing medium.