Nerine gibsonii is most suitably grown as a container subject in a sunny position. Its active growing season extends from early summer to mid-autumn, during which time it requires heavy watering about once per week, but in winter it can either be dried off completely, or watered far less often, about once per month. It tends to remain evergreen in temperate climates and it likes an acid, well-drained, sandy growing medium such as equal parts of coarse river sand and finely sifted, acid compost. In the southern hemisphere, 20-25 cm diameter plastic pots suit it well, but in cold climates of the northern hemisphere, terracotta containers are preferable, to ensure adequate aeration of the growing medium. The bulbs are planted with the top of the neck resting at or just below soil level. Once planted, they like to remain undisturbed for at least five years, only needing lifting and dividing when flowering performance diminishes markedly. The bulbs do not multiply as rapidly as many other Nerine species do, and they do not require supplementary feeding at all, as feeding has the effect of producing foliage at the expense of flowers.

This species is best propagated by seeds sown as soon as they are easily removed from the seed capsules. Sow the seeds evenly in deep seed trays or pots, in the same acid growing medium suggested for adult bulbs, and cover with a 1 cm layer of soil medium. Water well with a fine rose and place in a sunny position, under cover from heavy rain. Allow the seedlings to grow through their first winter, and lift them at the beginning of their third spring season and plant into permanent containers. Flowers can be expected for the first time during the third or fourth seasons, under ideal conditions.

The leaves, flowers, stems and bulbs of N. gibsonii are highly susceptible to attack by lily borer (amaryllis caterpillar), and the bulbs are often subject to the universal mealy bug scourge.