Entada rheedii is best propagated from seeds. However, it is a challenge to extract the individual seeds from the fruit. It is best to extract the seeds from the pod in summer, when it is completely dry and easy to open. One other challenge is the removal of the seed coat, as seeds might not geminate when they have not been scarified. For seeds that are collected on beaches after they have been transported for long distances by ocean currents, sand paper can be used to remove the seed coat. For seeds with a hard seed coat, the embryo can be exposed by drilling a hole in the seeds until the embryo is visible.

The scarified seeds should be soaked in water for 24 to 48 hours until they start to swell. Trays in which the seeds are to be sown, should be washed with Jeyes fluid and placed in the sun to kill pests and fungi. To sow the seeds, place potting mix into the trays with good drainage and saturate it completely with water. Sow the seeds 50 mm into the soil. For seeds where you have drilled a hole to expose the embryo, place the seed with the exposed part facing upwards.

After sowing the seeds, cover them with the potting mix and tamp them down using a tamping tool. Cover the tray with cling wrap to create a humid environment. Place the tray in an area that receives sufficient sunlight and water the seeds when the soil becomes slightly dry. The seed will germinate in 3 to 4 weeks. Transplant the seedling into individual pots with the same germination medium when they have the first four leaves. When transplanting the seedlings, make sure that the soil is wet to prevent damage to the roots.