The optimum sowing time for Ursinia nana is autumn or spring (March and September ). Seeds must be fresh and viable, and can be expected to germinate in about 6 to 8 days. Use a well-drained sowing medium. The medium must be slightly moist before sowing. Depth of sowing must be 1.5 cm. Cover the seeds with fine bark and water. The medium must never dry out completely and never be soaking wet. Watering must be average, to prevent damping off. A high percentage of seeds germinate, without dormancy. Seeds can be transplanted about 4–6 weeks after germination, when the seedlings have developed the second set of true leaves. This species requires a full sun position, in well-drained, sandy, gravel or loam soil.

This species is shown to best effect when planted in groups with other herbaceous perennials and annuals, where their bright yellow flowers combine well with other yellow, orange and pink flowered plants, and makes the bed more attractive. The purpose of planting perennials and annuals together, is to acquire various flowering patterns, flower colours and to attract beneficial insect pollinators. Good companion plants include Cotula duckittiae, Lobelia valida, Ursinia speciosa and U. calenduliflora and Dorotheanus bellidiformis. The background plants to be used can be Selago canescens, Helichrysum cymosum and Felicia echinata, which display some great colours, texture and structure within the flower bed and improve the quality and growth.