Cuttings should be harvested in autumn (March-May) or summer (December-February) in the southern Hemisphere, use a clean sharp knife. Take tip cuttings 15-20 cm long, just below the node. Carefully remove most of the leaves except for the top few. Dip the bottom of the cutting in a rooting hormone, which is optional, to speed up the rooting formation and plant out in moist river sand in a container. Place the container with cuttings in it in a controlled environment, such as a glasshouse, away from the natural elements. Spray twice daily in the morning and evening using a mist sprayer and keep the soil moist. Monitor the progress of these cuttings on a daily basis. Once the cuttings have rooted, transplant them into the same soil mix used for seed sowing viz. 2 parts red soil, 2 parts compost and 1 part river-sand.

Seed usually matures in late spring (October). Sow seed in autumn (March in the southern hemisphere) in a well-drained medium of 2 parts red soil, 2 parts compost and 1 part river-sand which is sifted, the seed should be lightly loosened and covered with the same mixture.

Fresh seed will only germinate optimally after 2 years because they are in a hard envelope. The seeds should be soaked in cold water for 12 hours or warm water for 3 hours. This allows water to penetrate the seed with the cold water treatment or soften the seed coat with the warm water treatment to facilitate germination. The seeds must be well-spaced to prevent competition of seedlings once they start to germinate after 10-20 days.

No pests are known to feed on this plant.

In a garden situation, Tetragonia fruticosa can be planted with appropriate companion plants such as Aloe microstigma (Worcester aloe) with its spotted leaves and Crassula rupestris (kebab bush) with its interesting arrangement of leaves, sometimes tinged a reddish colour with pink flowers, Didelta carnosa (coast salad bush) with its strange striking yellow flowers, Drosanthemum micans (Robertson vygie) with its beautiful flowers with red outer petals and chrome yellow inner petals and Othonna arbuscula (traap), with its yellow daisy flowers and bonsai appearance.