Not much is known about growing Indigofera denudata only that according to Loddiges, when it was cultivated in a greenhouse, it grew best in light loamy soil with a moderate water supply and plenty of fresh air, with extra care in winter. It grows well in full sun, in well-drained soil that has a pH of 7.0 to 8.0. It can mostly likely be propagated by seeds or cuttings, as are other species in the Fabaceae, however, propagating via seeds seems to be more successful than from cuttings when looking at the propagation of other Indigofera species.

Sow seeds in autumn, or in spring or summer, depending on whether seeds are sown indoors or outdoors. Plant the seeds in containers with only a thin layer of soil covering them, making sure the seeds are just below the surface. After sowing, lightly wet the soil. Place the containers in a warm area that gets plenty of sunlight but is not in direct sun, and keep them moist. The germination is successful when a long, thin stalk with 2 opposite leaves is produced. Transplant the seedlings into individual pots after the first pair of true leaves appear, taking care not to damage the roots.

For propagation using semi-hardwood cuttings, select a healthy plant that does not have flowers or flower buds. Make a clean, straight cut when cutting off the side shoots from the parent plant. Treat the cuttings with a suitable rooting gel or hormone powder. Make a hole for each of your cuttings and add the appropriate amount of potting medium to a clean container. Plant the cuttings gently and firmly in place. Place in a warm, dry, well-ventilated, well-lit area away from direct sun. Keep damp and repot when appropriate.

Indigofera plants don’t have any known significant pest or disease issues.