This plant grows in between the rocks, in serpentine soils that have low levels of nitrogen (N), phosphorus (P) and potassium (K). Ozoroa barbertonensis is one of the examples of plants that are tolerant of serpentine soils, which may make it easier to cultivate in gardens due to its resilience.

Ozoroa barbertonensis can be grown from seeds or cuttings. Fresh, good quality seeds can be sown in porous growing media with good drainage that is of good quality and free from diseases. Clean off the fleshy outer layer and sow the seeds in spring or early summer in a tray containing the well-drained soil, cover the seeds with vermiculite or sand to assist with germination and place where there is good light and air circulation. Keep the growing medium damp and start recording germination occurrence.

Remember to label your seeds with the following information: date, name of the seed, and name of the sower, so that the correct identity of your plantscan be guaranteed.

The horticultural principle for semi hardwood can be applied for cuttings. Cut a stem from a plant below the internode, about 10-15 cm long and remove the lower leaves. Place the cut end of the stem in a rooting hormone suitable for semi-hardwood cuttings and place in a well-prepared growing medium which can be a mixture of coarse sand and peat moss or a similar mixture.

The semi hardwood cuttings are propagated when the stems are not completely matured, at this point the wood is relatively firm but still flexible enough to bend.

When the plant is grown and well established in a garden, add a layer of mulch to keep the soil moist and reduce weeds. The plant requires good watering when young but once established, it can survive periods of drought and a fair amount of frost.